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Nanoparticles as an effective drug delivery system in COVID-19 - 09/10/21

Doi : 10.1016/j.biopha.2021.112162 
Neehasri Kumar Chowdhury a ,  Deepika b , Reshma Choudhury c , Gaurav Ambadas Sonawane d , Shankar Mavinamar e , Xiaoming Lyu f , Ramendra Pati Pandey g, , Chung-Ming Chang h,
a Department of Zoology, Gauhati University, Guwahati, Assam, India 
b Department of Biotechnology, Deenbandhu Choturam University, and Technology, Sonepat, Haryana, India 
c Department of Biotechnology, Royal Global University, Guwahati, Assam, India 
d Department of Pharmacy, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, India 
e Department of Botany, Karnataka State Akkamahadevi Women’s University, Vijayapura, India 
f Laboratory Medicine, The Third Affiliated Hospital, Southern Medical University, No.183 West Zhongshan Avenue, Guangzhou, China 
g Department of Biotechnology, SRM University, Delhi-NCR, Sonepat, India 
h Master & Ph.D. program in Biotechnology Industry, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan, ROC. 

Corresponding authors.

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Abstract

Background

The global healthcare sector has been dealing with a situation known as a novel severe acute respiratory syndrome (SARS-CoV-2) since the end of 2019. Covid-19 is an acronym for Covid-19 (Coronavirus Disease- 2019). It causes a respiratory infection that includes cold, sneezing and coughing, and pneumonia. In the case of an animal, it causes diarrhea and upper respiratory diseases. Covid-19 transmitted human to human via airborne droplets. First Covid-19 emerged in Wuhan market China and it spread rapidly throughout the World. As we know nanoparticles are a novel drug delivery system. They have various advantageous effects like increasing the efficacy of the drug, safety, etc. In this review, we study about the nanoparticles and summarize how it is effective during drug delivery system in Covid-19. Chitosan is a much focused biopolymeric nanoparticle. It delivers drugs to the specific target site. In a recent health crisis, chitosan nanoparticles are one of the ways to release drugs of Covid-19, and specifically in the lungs of the affected patients. We studied and extracted our data from various research papers, review papers, and some other articles.

Objective

The main goal is to study the nanoparticles and their future aspects which is an effective drug delivery system in Covid-19.

Methods

The bibliographic search was done through a systematic search. The terms “Nanoparticles”, “Covid-19 ”, “Drug delivery” etc. were used to search the databases/search engines like “Google Scholar”, “NCBI”, “PubMed”, “Science Direct” etc. These databases and search engines used here perform the limited criteria of search to conduct a systematic literature survey for the study and report writing. All the text from the articles and research papers were studied and analyzed. The various articles and research papers were used in writing this report and all of which are mentioned in the reference section of this report.

Conclusion

Our current studies reveal that nanoparticles may prove very helpful in the delivery of drugs for Covid-19 treatment. Many cases showed that patients, where drugs are delivered with the help of nanoparticles, produced very few side effects.

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Graphical Abstract




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Highlights

Almost every antiviral pharmaceutical system can be nano-scaled to improve its properties.
Nanoparticles as delivery vehicles can improve the effectiveness of drug delivery.
Nanomedicines and Nano- drug delivery system have shown promising effectiveness against the Covid 19 as treatments.
Numerous subsidies to advance the nanoparticular antiviral field are provided for public health and financially.

Il testo completo di questo articolo è disponibile in PDF.

Keywords : Covid-19, Nanoparticles, Drug delivery system, Bibliographic search, Treatment


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