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Reports analysis of psychotropic drugs related adverse reactions in Australia and Poland during the COVID 19 pandemic - 29/04/23

Doi : 10.1016/j.biopha.2023.114681 
Daria Schetz a, , Tara Elizabeth Scott a, Wojciech Waldman b, Jacek Sein Anand b, Marek Wiergowski c, Ivan Kocić a
a Department of Pharmacology, Faculty of Medicine, Medical University of Gdańsk, Poland 
b Division of Clinical Toxicology, Faculty of Health Sciences with the Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, Poland 
c Department of Forensic Medicine, Faculty of Medicine, Medical University of Gdańsk, Poland 

Corresponding author.

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Abstract

Background

The COVID-19 pandemic has caused significant changes to the global health care system

Aims

It is unknown whether the COVID-19 pandemic influenced the occurrence of adverse drug reactions (ADR) of antidepressive agents, benzodiazepines, and antipsychotics plus mood stabilizers (AaMS). The study was designed in order to compare the incidence of ADR during the COVID-19 pandemic with the period preceding the pandemic in Poland and Australia, different in terms of their COVID-19 prevention strategy.

Method

We analysed ADR from the three surveyed pharmacological groups of drugs observed in Poland and Australia in the period prior to, and during the COVID-19 pandemic

Results

In Poland, a noticeable increase in the reported ADR of the assessed drug groups was observed during the COVID-19 pandemic. The highest was for antidepressive agents, but the reporting of ADR for benzodiazepines and AaMS drugs also increased significantly. In the case of ADR in Australian patients, the increase in the number of reported ADR for antidepressive agents was modest compared to that seen in Poland, but still noticeable, and there was a significant increase in ADR for benzodiazepines

Conclusions

This study showed that the COVID-19 pandemic has had an impact on the incidence of ADR reported among both Polish and Australian patients but the modality of this was different.

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Graphical Abstract




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Highlights

During the pandemic, increases in the reporting of adverse reactions of psychotropic drugs were seen in Poland.
In Poland was an increase in the reporting of severe adverse drug reactions compared to the period before the COVID-19 pandemic.
In Australia, during the pandemic a substantial upsurge in the reporting of adverse drug reaction was found in the case of benzodiazepines.
The study highlighted the differences in adverse drug reaction reporting systems between Poland and Australia.

Il testo completo di questo articolo è disponibile in PDF.

Keywords : Psychotropic drugs, Poland, Australia, COVID-19, Adverse drug reactions


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© 2023  The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
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