Entrustable professional activities (EPAs) are set to assess residents’ capacity to perform professional units close to the context of their future clinical practice. The aim was to define a concise list of EPAs covering the broad specialty of Physical and Rehabilitation Medicine (PRM) to implement a systematic and consistent assessment of trainees’ competencies during their residency. A list of EPAs was developed based on a literature review and working group. This list was then submitted to academic PRM professors for validation via a Delphi process. Two rounds were planned with intermediate and final discussion meetings by an external steering committee. Ten EPAs were developed in a first draft. Each of the seven parts of the EPAs obtained validation through the Delphi process. A list of 11 clinical contexts of application was approved to integrate the EPAs in the different areas of PRM. The next step will be the deployment of these EPAs for the validation of residency internships.