Pruritus and anxiety symptoms in chronic spontaneous urticaria are associated with altered functional connectivity of the brain - 18/06/25
Abstract |
Background |
Previous studies have found differences in spontaneous neural activity in multiple brain regions in CSU patients, such as the inferior orbitofrontal cortex. However, the current research on CSU patients is still dominated by brain region response, and there is a lack of evidence for the correlation between different brain regions. To elucidate the underlying mechanisms of interactions between different brain regions in CSU patients, we compared changes in FC between CSU patients and HCs.
Methods |
53 patients with CSU and 31 HCs were recruited. The UAS7, VAS-P, DLQI, HAMA, and HAMD were collected to evaluate the changes in clinical symptoms in CSU. ORBinf-L was used as the seed point for whole brain FC analysis. Seed-based FC analysis was used to assess functional changes in the brain regions of the subjects.
Results |
Compared with HCs, the FC values of the Caudate-L was increased in CSU patients, and the FC values was positively correlated with the VAS-P. CSU patients had decreased FC values in the Hippocampus-R, and were negatively correlated with the values of HAMA.
Conclusions |
Our results revealed that CSU patients demonstrate aberrant connectivity in specific brain circuits—particularly the ORBinf-L to Caudate-L and ORBinf-L to Hippocampal-R pathways, which correlates with their pruritus severity and anxiety levels.
Trial registration number |
ChiCTR2200064563
Le texte complet de cet article est disponible en PDF.Keywords : Chronic spontaneous urticaria, Pruritus, Anxiety, Functional connectivity, Caudate, Hippocampus
Plan
Vol 52 - N° 4
Article 101355- juin 2025 Retour au numéro
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