Longitudinal associations of carotid artery stiffness with progression of cerebrovascular disease, incident dementia and cognitive decline in older adults - 02/07/25
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Abstract |
Background |
Carotid artery stiffness is associated with cerebrovascular disease (CeVD) and cognitive impairment, but evidence for its longitudinal effects on progression of CeVD and cognitive decline are limited.
Objectives |
To evaluate the longitudinal associations of carotid artery stiffness with CeVD progression, incident dementia, and cognitive decline.
Design |
Longitudinal analyses from a memory-clinic cohort with a follow-up of 2 years.
Setting |
A memory-clinic study.
Participants |
194 participants (mean age=80, 63 % female) with or without cognitive impairments provided consent to take part in the study.
Measurements |
Participants underwent carotid ultrasonography, brain MRI, and neuropsychological assessments were at baseline and follow-up. Carotid stiffness measures included ß-index, elastic modulus (Ep), and pulse wave velocity-ß (PWV-ß). CeVD markers included white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMBs) and cortical infarcts. Cognition was assessed with a neuropsychological battery.
Results |
After 2 years, incident CeVD cases included lacunes (15.7 %), CMBs (23.8 %), and cortical infarcts (7.6 %). ß-index (ß=0.78, p < 0.001), Ep (ß=0.94, p < 0.001), and PWV-ß (ß=0.15, p = 0.003) were independently associated with WMH progression. Ep (ß=-0.15, p = 0.007) and PWV-ß (ß=-3.68, p = 0.007) were independently associated with visuomotor speed decline. No association was found with incident lacunes, CMBs or dementia.
Conclusion |
Carotid stiffness progression is associated with WMH progression and visuomotor speed decline.
Le texte complet de cet article est disponible en PDF.Keywords : Alzheimer's disease, Carotid artery stiffness, Cerebrovascular disease, Cognitive decline
Plan
Vol 12 - N° 6
Article 100127- juin 2025 Retour au numéro
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