Preprocedural frailty status and short- and long-term mortality risk after endovascular therapy in elderly acute ischemic stroke patients - 04/09/25
, Renjing Zhu a, b, c, g, ⁎
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Abstract |
Objectives |
To evaluate the Laboratory-based Frailty Index (FI-LAB) for predicting mortality following endovascular therapy (EVT) in elderly patients with large vessel occlusion acute ischemic stroke (LVO-AIS).
Methods |
This retrospective study enrolled 382 patients aged ≥60 years undergoing EVT. FI-LAB was constructed using 44 preprocedural laboratory parameters. Primary endpoint was 12-month all-cause mortality; secondary endpoint was 14-day mortality. Cox proportional hazards models assessed FI-LAB-mortality associations.
Results |
Among 382 patients, 68.8% exhibited varying degrees of frailty. In fully adjusted models, compared with robust patients, frail patients demonstrated a 1.82-fold increase in 14-day mortality risk (P = 0.012) and a 2.61-fold increase in 12-month mortality risk (P < 0.001). Each 0.1-unit increase in FI-LAB was associated with a 51% increase in 14-day mortality risk (P = 0.001) and a 63% increase in 12-month mortality risk (P < 0.001).
Conclusions |
FI-LAB independently predicts short-term and long-term mortality following EVT in elderly stroke patients, offering objective risk stratification for clinical decision-making.
Le texte complet de cet article est disponible en PDF.Keywords : Laboratory frailty index, Risk stratification, Geriatric assessment, Mechanical thrombectomy, Prognostic biomarker, Large vessel occlusion
Plan
Vol 29 - N° 11
Article 100673- novembre 2025 Retour au numéro
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