Periorificial dermatitis: Pathophysiology, diagnosis, and management - 17/04/26

Doi : 10.1016/j.jaad.2025.10.138

Lorena A. Acevedo-Fontanez, BS ^a, Abizairie Sánchez-Feliciano, BS ^a, Sherry Ershadi, BS ^a, Jason Reichenberg, MD, MBA ^b, Lawrence F. Eichenfield, MD ^c,^d, John S. Barbieri, MD, MBA ^a,^⁎

^a Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts

^b Department of Dermatology, Dell Medical School at the University of Texas at Austin, Austin, Texas

^c Departments of Dermatology and Pediatrics, University of California San Diego, La Jolla, California

^d Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California

^∗ Correspondence to: John S. Barbieri, MD, MBA, Department of Dermatology, Brigham and Women’s Hospital, 221 Longwood Ave, Boston, MA 02115. Department of Dermatology Brigham and Women’s Hospital 221 Longwood Ave Boston MA 02115

Abstract

Periorificial dermatitis is a chronic papulopustular facial dermatitis. Despite being frequently encountered in clinical practice and associated with significant effects on quality of life, its etiology remains incompletely understood, and no therapies are specifically approved by the US Food and Drug Administration for its treatment. In this review, the current mechanistic understandings of periorificial dermatitis pathogenesis are discussed, including the role of inciting factors, skin barrier dysfunction, inflammation, and the microbiome. In addition, we review the diagnostic features of periorificial dermatitis and how to distinguish it from clinical mimickers. Finally, treatment is discussed, including skincare, topical, and systemic therapies.

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Key words : causes, diagnosis, management, pathophysiology, perioral dermatitis, periorificial dermatitis, treatment, triggers

Abbreviation used : POD

Plan

	Authors Acevedo-Fontanez and Sánchez-Feliciano are cofirst authors.
	Funding sources: None.
	IRB approval status: Not applicable.

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Vol 94 - N° 5

P. 1483-1492 - mai 2026 Retour au numéro

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Periorificial dermatitis: Pathophysiology, diagnosis, and management - 17/04/26

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