Higher B-cell activating factor levels at birth are positively associated with maternal dairy farm exposure and negatively related to allergy development - 06/10/15
, Bill Hesselmar, MD, PhD c, Inger Nordström, BSc a, Ingegerd Adlerberth, MD, PhD b, Agnes E. Wold, MD, PhD b, Anna Rudin, MD, PhD aAbstract |
Background |
A high proportion of circulating immature/naive CD5+ B cells during early infancy is a risk factor for allergy development. B-cell activating factor (BAFF) is an important cytokine for B-cell maturation.
Objective |
We sought to investigate whether BAFF levels are related to environmental exposures during pregnancy and early childhood and whether BAFF levels are associated with postnatal B-cell maturation and allergic disease.
Methods |
In the FARMFLORA study, including both farming and nonfarming families, we measured BAFF levels in plasma from mothers and their children at birth and at 1, 4, 18, and 36 months of age. Infants' blood samples were also analyzed for B-cell numbers and proportions of CD5+ and CD27+ B cells. Allergic disease was clinically evaluated at 18 and 36 months of age.
Results |
Circulating BAFF levels were maximal at birth, and farmers' children had higher BAFF levels than nonfarmers' children. Higher BAFF levels at birth were positively associated with proportions of CD27+ memory B cells among farmers' children and inversely related to proportions of CD5+ immature/naive B cells among nonfarmers' children. Children with allergic disease at 18 months of age had lower cord blood BAFF levels than nonallergic children. At birth, girls had higher BAFF levels and lower proportions of CD5+ B cells than boys.
Conclusions |
Farm exposure during pregnancy appears to induce BAFF production in the newborn child, and high neonatal BAFF levels were associated with more accelerated postnatal B-cell maturation, which lend further strength to the role of B cells in the hygiene hypothesis.
Le texte complet de cet article est disponible en PDF.Key words : Prospective birth cohort, B-cell activating factor, dairy farm, pregnancy, immature/naive B cells, memory B cells, hygiene hypothesis, allergy, sex
Abbreviations used : APC, BAFF, FITC, OPLS, TLR, VIP
Plan
| Supported by the Swedish Research Council (grant K2012-57X-22047-01-6); Region Västra Götaland (agreement concerning research and education of doctors; ALF; grant ALFGBG-143331); the Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland (grant VGFOUREG-315041); the Torsten and Ragnar Söderberg's Foundation (grant M112/11); the Swedish Society of Medicine; the Göteborg Medical Society/Swedish Order of Freemasons in Gothenburg; the Magnus Bergvall foundation; and the IngaBritt and Arne Lundberg's foundation. |
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| Disclosure of potential conflict of interest: This study was funded by the Swedish Research Council (grant K2012-57X-22047-01-6); the Region Västra Götaland (agreement concerning research and education of doctors; ALF; grant ALFGBG-143331); the Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland (grant VGFOUREG-315041); the Torsten and Ragnar Söderberg's Foundation (grant M112/11); the Swedish Society of Medicine, the Göteborg Medical Society/Swedish Order of Freemasons in Gothenburg; the Magnus Bergvall foundation; and the IngaBritt and Arne Lundberg's foundation. I. Adlerberth has received consultancy fees from Premune and Swecure AB, as have B. Hesselmar, A. E. Wold, and A. Rudin. A. E. Wold also receives compensation for board membership. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 136 - N° 4
P. 1074 - octobre 2015 Retour au numéro
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