Clinical Factors Associated with Response to Treatment in a Population of Depressed Patients Treated in General Practice: the Hedonie Study - 07/10/15
Résumé |
Introduction |
In major depressive disorder (MDD), response and remission are the goals of treatment strategies.
Aim |
To describe factors associated with response and remission in MDD, we conducted a longitudinal study exploring response to treatment in a large sample of depressed patients in general practice.
Method |
General practitioners (GPs) recruited depressed patients consecutively and evaluated them using the QIDS-SR and the Snaith-Hamilton Pleasure Scale. Patients were treated with agomelatine and evaluated after 6 to 8 weeks. Response was identified as a 50% improvement in QIDS score and remission as a QIDS score below 5 at endpoint. We conducted a logistic regression to identify the variables associated with response and remission.
Results |
1752 patients were included (62.4% women, 37.6% men). Average QIDS-SR score was 15.7 (SD=4.3). The average duration of the current episode was 6.1 weeks (SD=6.2) and it was the first episode for 65.7% of the patients. In 91.15% of the patients, anhedonia was considered as severe (score above 5). Level of anhedonia, duration of the episode and recurrence were associated with a higher probability of response to treatment (respectively p< .0001, p= 0.0181 and p= 0.0323). Remission was correlated with the absence of recurrence and professional activity (p< .0001).
Conclusion |
Level of anhedonia and the characteristics of the episode are associated with the probability of achieving a response. Taking into account these parameters in order to specify treatment strategies is one way to improve the course of MDD.
Le texte complet de cet article est disponible en PDF.Vol 30 - N° S1
P. 639 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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