Fetal programming and systemic sclerosis - 02/12/15

Doi : 10.1016/j.ajog.2015.07.034

Gianpaolo Donzelli, MD, PhD ^a,^⁎ , Giulia Carnesecchi, MD ^c, Carolina Amador, MD, PhD ^a, Mariarosaria di Tommaso, MD, PhD ^d, Luca Filippi, MD ^a, Roberto Caporali, MD ^e, Veronica Codullo, MD, PhD ^e, Valeria Riccieri, MD ^f, Guido Valesini, MD ^f, Armando Gabrielli, MD ^g, Roberta Bagnati, MD ^g, Kathleen S. McGreevy, PhD ^b, Salvatore De Masi, MD ^a, Marco Matucci Cerinic, MD, PhD ^c
^a Department of Fetal-Neonatal Medicine, Meyer Children’s Hospital, University of Florence, Florence, Italy
^b Research, Innovation, and International Relations Office, Meyer Children’s Hospital, University of Florence, Florence, Italy
^c Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
^d Department of Health Sciences, University of Florence, Florence, Italy
^e Department of Rheumatology, University and IRCCS Foundation, Policlinico San Matteo, Pavia, Italy
^f Department of Internal Medicine and Clinical Specialties, Rheumatology Unit, “La Sapienza” University, Rome, Italy
^g Institute of General Clinical Medicine, Hematology, and Clinical Immunology, University of Ancona, Ancona, Italy

^∗Corresponding author: Gianpaolo Donzelli, MD, PhD.

Abstract

Objective

This study investigated whether birthweight is linked to an increased risk of the development of systemic sclerosis.

Study Design

This was a multicenter case-control study with perinatal data that were obtained from 332 cases with systemic sclerosis and 243 control subjects. Birthweight was treated as a dichotomous variable (<2500 g vs ≥2500 g); low birthweight was defined as a weight <2500 g; small for gestational age was defined as birthweight <10th percentile for gestational age adjusted for sex. The relationship between systemic sclerosis and both low birthweight and small for gestational age was expressed with the crude (univariate analysis) and adjusted (multivariate analysis) odds ratio (OR).

Results

Significantly increased ORs were observed in the univariate analysis for low birthweight (OR, 2.59; 95% confidence interval [CI], 1.39–5.05) and small for gestational age (OR, 2.60; 95% CI, 1.34–5.32) subjects. Similarly increased risks were confirmed for both conditions in the multivariate analysis (OR, 3.93; 95% CI, 1.92–8.07; and OR, 2.58; 95% CI, 1.28–5.19), respectively.

Conclusion

Low birthweight and small for gestational age at birth are risk factors for the adult onset of systemic sclerosis.

Le texte complet de cet article est disponible en PDF.

Key words : autoimmune disease, birthweight, epigenetics, fetal programming, scleroderma

Plan

Materials and Methods

Results

Comment

	The authors report no conflict of interest.
	Cite this article as: Donzelli G, Carnesecchi G, Amador C, et al. Fetal programming and systemic sclerosis. Am J Obstet Gynecol 2015;213:839.e1-8.

Export

Vol 213 - N° 6

P. 839.e1-839.e8 - décembre 2015 Retour au numéro

Article précédent

Evidence of perturbations of the cytokine network in preterm labor
Roberto Romero, Jean-Charles Grivel, Adi L. Tarca, Piya Chaemsaithong, Zhonghui Xu, Wendy Fitzgerald, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Leonid Margolis

| Article suivant

Impact of fetal chromosomal disorders on maternal blood metabolome: toward new biomarkers?
Joana Pinto, Lara Monteiro Almeida, Ana Sofia Martins, Daniela Duarte, Maria Rosário Marques Domingues, António Sousa Barros, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Isabel Marques Carreira, Ana Maria Gil

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Fetal programming and systemic sclerosis - 02/12/15

Abstract

Objective

Study Design

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL