Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization - 07/01/16
Abstract |
Background |
Studies of children's blood lipid profiles in relation to asthma are few, and the results are ambiguous.
Objective |
We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children.
Methods |
High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were measured at ages 5 to 7 years in the Copenhagen Prospective Studies on Asthma in Childhood2000 at-risk birth cohort. Asthma and allergic rhinitis were diagnosed based on predefined algorithms at age 7 years along with assessments of lung function, bronchial responsiveness, fraction of exhaled nitric oxide (Feno), and allergic sensitization. Associations between lipid levels and clinical outcomes were adjusted for sex, passive smoking, and body mass index.
Results |
High levels of low-density lipoprotein cholesterol were associated with concurrent asthma (adjusted odds ratio [aOR], 1.93; 95% CI, 1.06-3.55; P = .03) and airway obstruction: 50% of forced expiratory flow (aβ coefficient, −0.13 L/s; 95% CI, −0.24 to −0.03 L/s; P = .01) and specific airway resistance (aβ coefficient, 0.06 kPa/s; 95% CI, 0.00-0.11 kPa/s; P = .05). High levels of high-density lipoprotein cholesterol were associated with improved specific airway resistance (aβ coefficient, −0.11 kPa/s; 95% CI, −0.21 to −0.02; P = .02), decreased bronchial responsiveness (aβ coefficient, 0.53 log-μmol; 95% CI, 0.00-1.60 log-μmol; P = .05), decreased risk of aeroallergen sensitization (aOR, 0.27; 95% CI, 0.01-0.70; P = .01), and a trend of reduced Feno levels (aβ coefficient, −0.22 log-ppb; 95% CI, −0.50 to 0.01 log-ppb; P = .06). High triglyceride levels were associated with aeroallergen sensitization (aOR, 2.01; 95% CI, 1.14-3.56; P = .02) and a trend of increased Feno levels (aβ coefficient, 0.14 log-ppb; 95% CI, −0.02 to 0.30 log-ppb; P = .08).
Conclusion |
The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy are systemic disorders with commonalities with other chronic inflammatory disorders.
Le texte complet de cet article est disponible en PDF.Key words : Blood lipids, asthma, child, respiratory function tests, inflammation
Abbreviations used : aOR, BMI, COPSAC2000, Feno, HDL-C, LDL-C, PC, PCA, sRaw
Plan
| COPSAC is funded by private and public research funds all listed on www.copsac.com. The Lundbeck Foundation (R16-A1694), The Ministry of Health (903516), Danish Council for Strategic Research, and Capital Region Research Foundation have provided core support for COPSAC. B.L.K.C. was supported by the Thrasher Research Award. The funding agencies did not have any influence on study design, data collection and analysis, decision to publish or preparation of the manuscript. Thermo Fisher Scientific Inc sponsored the IgE analyses. No pharmaceutical company was involved in the study. The funding agencies did not have any role in design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript. |
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| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 137 - N° 1
P. 68 - janvier 2016 Retour au numéro
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