A cluster-analytical approach toward real-world outcome in outpatients with stable schizophrenia - 06/02/16
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Abstract |
Background |
This study aims to empirically identify profiles of functioning, and the correlates of those profiles in a sample of patients with stable schizophrenia in a real-world setting. The second aim was to assess factors associated with best profile membership.
Methods |
Three hundred and twenty-three outpatients were enrolled in a cross-sectional study. A two-step cluster analysis was used to define groups of patients by using baseline values for the Heinrichs-Carpenter Quality of Life Scale (QLS) total score. Logistic regression was used to construct models of class membership.
Results |
Our study identified three distinct clusters: 50.4% of patients were classified in the “moderate” cluster, 27.9% in the “poor” cluster, 21.7% in the “good” cluster. Membership in the “good” cluster versus the “poor” cluster was characterized by less severe negative (OR=.832) and depressive symptoms (OR=.848), being employed (OR=2.414), having a long-term relationship (OR=.256), and treatment with second-generation antipsychotics (SGAs) (OR=3.831). Nagelkerke R2 for this model was .777.
Conclusions |
Understanding which factors are associated with better outcomes may direct specific and additional therapeutic interventions, such as treatment with SGAs and supported employment, in order to enhance benefits for patients, as well as to improve the delivery of care in the community.
Le texte complet de cet article est disponible en PDF.Keywords : Schizophrenia, Quality of life, Real-world outcome, Milestones, Cluster analysis
Plan
Vol 32
P. 48-54 - février 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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