Continuous Norethisterone Acetate versus Cyclical Drospirenone 3 mg/Ethinyl Estradiol 20 ?g for the Management of Primary Dysmenorrhea in Young Adult Women - 18/02/16
, Nedal Nawaiseh, MD, PhD 2Abstract |
Study Objective |
To evaluate the efficacy of continuous norethisterone acetate (NET-A), 5 mg (group N) vs cyclical combined oral contraceptive pill (COC) consisting of drospirenone 3 mg/ethinyl estradiol 20 μg pills (group P) in treating dysmenorrhea in young adult women.
Design, Setting, and Participants |
This prospective, open-label, nonrandomized study included 38 Jordanian patients: 20 patients in group N and 18 patients in group P.
Interventions |
Continuous NET-A 5 mg daily or cyclical COC.
Main Outcome Measures |
Pain scores, adverse effects, analgesic use, school absence, and cost.
Results |
Thirty-eight patients used NET-A or COC for 6 months. All participants had almost the same starting levels of visual analogue scale (VAS) scores. Both drugs were similar in suppressing dysmenorrhea at the 3-month follow-up visit; VAS score mean (±SD) in group N and P were 1.30 ± 1.22 and 1.28 ± 0.83 (P = .22), respectively, and after 6 months, with mean VAS scores (±SD) of 1.30 ± 1.22 and 1.28 ± 0.83, respectively (P = .95). The cost of the treatment in the N group was much less than in the P group. Participants in the N group were less likely to use pain killers: 20% and 44% in the N and P groups, respectively (P = .006) in the first month and only 5% and 17% (P = .019) in the N and P groups, respectively, at the 3-month follow-up, and none of them used any analgesics at the 6-month follow-up.
Conclusion |
A continuous NET-A regimen is a well tolerated, effective, and inexpensive option for dysmenorrhea treatment and was as good as COC.
Le texte complet de cet article est disponible en PDF.Key Words : Primary dysmenorrhea, Young adult women, Norethisterone acetate, Combined oral contraceptive pill
Plan
| The authors indicate no conflicts of interest. |
Vol 29 - N° 2
P. 143-147 - avril 2016 Retour au numéro
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