The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis - 01/04/16
, Jianan Xiao b, Qingbing Wang b, Yanjun Wang b, Yong Zhang b, Dongxiao Bai bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Background and objective |
The prognostic value of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) in gastric cancer remains controversial. To further investigate this relationship, we performed meta-analyses to systematically review the association between LGR5 expression and various clinical parameters in gastric cancer patients.
Method |
Eligible studies from PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), Wangfang (Database of Chinese Ministry of Science & Technology) and CBM (China Biological Medicine) databases were evaluated to investigate the association of LGR5 expression with overall survival (OS) and clinicopathological features of gastric cancer.
Results |
LGR5 overexpression was significantly associated with poor OS in patients with gastric cancer (HR 1.66, 95% CI 1.02–2.69). LGR5 overexpression was also significantly associated with TNM stage (TIII/TIV vs TI/TII: OR 5.42, 95% CI 1.02–28.72) and lymph node metastasis (positive vs negative: OR 2.30, 95% CI 1.06–5.0).
Conclusions |
Our meta-analysis indicates that LGR5 may be a predictive factor for invasion and metastasis, and poor prognosis in patients with gastric cancer.
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Vol 40 - N° 2
P. 246-253 - avril 2016 Retour au numéro
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