Substance abuse and quality of life in chronic hepatitis C patients receiving antiviral treatment - 13/04/16
Résumé |
Introduction |
Chronic hepatitis C virus (HCV) is one of world's most important chronic infections. HCV can be treated using interferon-alpha (IFNα) and ribavirin (RBV). HCV, IFNα and RBV are known to impair mental and physical life quality. Many HCV-infected individuals have life-prevalence of substance use disorder (SUD).
Objectives |
To study life quality (SF-36) in HCV patients with SUD history during antiviral treatment.
Methods |
SF-36 questionnaire was assessed in 384 HCV patients at baseline, and at 4, 12, 24, and 48weeks of treatment. ANCOVA models were used to study the association of SF-36 scores and potential risk factors at baseline. Risk factors from baseline scores over time were studied through linear mixed models, adjusting for baseline scores.
Results |
At baseline, SUD men had worse mental (P=0.03) and physical health (P=0.022), and younger patients had worse social functioning (P=0.011), and mental (P=0.001) but better physical health (P<0.001). Fig. 1, Fig. 2 show the results of mental and physical life quality during treatment from baseline.
Conclusions |
This study emphasizes the decrease in life quality in HCV patients with SUD before and during antiviral treatment.
Grant |
Instituto de Carlos III-FIS: PSICOCIT-PI110/01827,EU “One way to make Europe”, Ministerio de Economia y Competitividad (MTM2012-38067-C02-01), and support of SGR/2014/1135.
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Vol 33 - N° S
P. S142 - mars 2016 Retour au numéro
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