Factors associated with post-ERCP pancreatitis and the effect of pancreatic duct stenting in a pediatric population - 01/06/16
Abstract |
Background |
Risk factors for the development of post-ERCP pancreatitis (PEP) have not been identified in the pediatric population. It remains unclear what constitutes appropriate prophylaxis in this patient population.
Objectives |
To assess the prevalence and severity of PEP in the pediatric population and identify factors associated with developing PEP and to evaluate the effect of prophylactic pancreatic duct stenting in high-risk patients.
Design |
Retrospective analysis of an ERCP database at a single large pediatric center.
Setting |
Academic center.
Patients |
A total of 432 ERCPs performed on 313 patients younger than 19 years of age from January 2004 to October 2013.
Intervention |
ERCP for any indication.
Main Outcome Measurements |
Rates and severity of PEP, preprocedural and procedural risk factors for the development of PEP, and the effect of pancreatic stents on preventing PEP in high-risk patients.
Results |
PEP occurred after 47 procedures (prevalence, 10.9%). Thirty-four cases were mild, 9 were moderate, and 4 were severe. There was no mortality. On multiple logistic analysis, pancreatic duct injection (P < .0001; odds ratio 30.8; 95% confidence interval [CI], 9.1-103.9) and pancreatic sphincterotomy (P < .01; OR 3.8; 95% CI, 1.6-9.8) were positively associated with PEP. A history of chronic pancreatitis was negatively associated with PEP (P < .05; OR 0.37; 95% CI, 0.15-0.93). On subset analysis, placing a prophylactic pancreatic stent was associated with significantly increased rates of PEP in patients with pancreatic duct injection compared with those who had no attempt at stent placement (P <.01). Two patients with severe pancreatitis had prophylactic pancreatic stents in place.
Limitations |
Retrospective investigation.
Conclusions |
In the pediatric population, pancreatic duct injection and pancreatic sphincterotomy are associated with significantly increased rates of PEP, whereas a history of chronic pancreatitis is negatively associated. Prophylactic pancreatic stenting is associated with higher rates of PEP in high-risk patients and does not eliminate severe PEP.
Le texte complet de cet article est disponible en PDF.Abbreviations : CI, OR, PEP, SOD, SOM
Plan
| DISCLOSURE: All authors disclosed no financial relationships relevant to this article. |
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| See CME section; p. 1439. |
Vol 81 - N° 6
P. 1408-1416 - juin 2015 Retour au numéro
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