Complete Myeloperoxidase Deficiency: Beware the “False-Positive” Dihydrorhodamine Oxidation - 25/08/16
Doi : 10.1016/j.jpeds.2016.05.047
Ki Lee Milligan, MD 1, ⁎ 
, Daphne Mann, BSN 2, 3, Amy Rump, MSN, CRNP 2, 3, Victoria L. Anderson, MSN, CRNP 2, Amy P. Hsu, BA 2, Douglas B. Kuhns, PhD 4, Christa S. Zerbe, MD 2, Steven M. Holland, MD 2
, Daphne Mann, BSN 2, 3, Amy Rump, MSN, CRNP 2, 3, Victoria L. Anderson, MSN, CRNP 2, Amy P. Hsu, BA 2, Douglas B. Kuhns, PhD 4, Christa S. Zerbe, MD 2, Steven M. Holland, MD 2 1 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
2 Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
3 Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD
4 Clinical Services Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD
∗Reprint requests: Ki Lee Milligan, MD, c/o Steven M. Holland, MD, NIH, CRC B3-4141 MSC 1684, Bethesda, MD 20892.c/o Steven M. Holland, MD, NIHCRC B3-4141 MSC 1684BethesdaMD20892
Abstract |
Myeloperoxidase deficiency is the most common inherited phagocyte disorder (1:2000) and causes an abnormal dihydrorhodamine oxidation test, which also is seen in chronic granulomatous disease. A patient with Candida meningitis and low dihydrorhodamine oxidation signal was diagnosed with chronic granulomatous disease but actually had compound heterozygous myeloperoxidase deficiency.
Le texte complet de cet article est disponible en PDF.Keywords : candida, chronic granulomatous disease, dihydrorhodamine, myeloperoxidase deficiency, neutrophil
Abbreviations : CGD, DHR, EPO, MPO, NBT
Plan
| Supported by the Division of Intramural Research, the National Institute of Allergy and Infectious Diseases and, the National Cancer Institute/National Institutes of Health (HHSN261200800001E). The content of this report does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does it imply endorsement by the US Government. The authors declare no conflicts of interest. |
© 2016
Publié par Elsevier Masson SAS.
Vol 176
P. 204-206 - septembre 2016 Retour au numéro
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