Accelerated T-cell activation and differentiation of polar subsets characterizes early atopic dermatitis development - 09/11/16

Doi : 10.1016/j.jaci.2016.04.052

Hitokazu Esaki, MD ^a,^b,^{^{∗
These authors contributed equally to this work.}}, Tali Czarnowicki, MD, MSc ^a,^{^{∗
These authors contributed equally to this work.}}, Juana Gonzalez, PhD ^c, Margeaux Oliva, BA ^b, Sreya Talasila, MD ^d, Isabel Haugh, MD ^d, Giselle Rodriguez, BA ^d, Lauren Becker, MD ^d, James G. Krueger, MD, PhD ^a, Emma Guttman-Yassky, MD, PhD ^a,^b,^{^{‡
These authors contributed equally to this work.}}, Amy S. Paller, MD ^d,^{^{‡
These authors contributed equally to this work.}}
^a Laboratory for Investigative Dermatology, Rockefeller University, New York, NY
^c Translational Technology Core Laboratory, Rockefeller University, New York, NY
^b Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY
^d Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill

Supported by a research grant to E.G.-Y. and A.S.P. from the LEO Foundation (research grant no. 0266-2572, GCO no. 13-1310). T.C. was cosponsored by the Center for Basic and Translational Research on Disorders of the Digestive System through the generosity of the Leona M. and Harry B. Helmsley Charitable Trust. J.G. was supported in part by grant no. UL1TR0000 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program. J.G.K. was supported by grant no. 5UL1RR024143-02 from the National Center for Research Resources (NCRR), a component of the NIH, and the NIH Roadmap for Medical Research. Blood acquisition was supported by the Northwestern University Skin Disease Research Center (NIAMS P30AR057216).

Disclosure of potential conflict of interest: E. Guttman-Yassky is a board member for Sanofi Aventis, Regeneron, Stiefel/GlaxoSmithKline, Medimmune, Celgene, Anacor, and Leo Pharma; has consultant arrangements with Regeneron, Sanofi Aventis, Medimmune, Celgene, Stiefel/GlaxoSmithKline, Celsus, BMS, Amgen, and Drais; and has received grants from Regeneron, Celgene, BMS, and Janssen. J. G. Krueger has received personal fees and money to his institution from Pfizer, Janssen, Lilly, Merck, Novartis, Kadmon, Dermira, Boehringer, and BMS; has received money to his institution from Amgen, Innovaderm, Kyowa, and Parexel; and has received personal fees from Serono, Biogen Idec, Delenex, AbbVie, Sanofi, Baxter, Xenoport, and Kineta. The rest of the authors declare that they have no relevant conflicts of interest.

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Vol 138 - N° 5

P. 1473 - novembre 2016 Retour au numéro

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Accelerated T-cell activation and differentiation of polar subsets characterizes early atopic dermatitis development - 09/11/16

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