Despite appropriate treatment, 30–40% of depressed patients, both unipolar and bipolar, do not achieve improvement, with high morbidity and mortality. For bipolar patients another risk is the switch into mania due to antidepressant treatment. The concern about the switch, suggests to administer antidepressants at lower doses, in combination with mood stabilizers and second generation anti-psychotics.

We performed an observational study on a sample of 23 bipolar patients treated with ECT for severe TRD in last 3years, in order to evaluate the risk of switch.

Twenty-three bipolar inpatients, undergoing bitemporal ECT twice/week, with MECTA spectrum device. Main demographic and clinical data collected. Hamilton rating scale for depression (HAM-D). Clinical response defined as 50% reduction of HAM-D score at the endpoint from baseline; remission as HAM-D score at the endpoint<8. Young Mania rating scale (YMRS) weekly in order to assess switch into mania.

Thirteen (56.5%) females, 10 (43.5%) males, mean age 60.1±10.3years. Mean age at onset 35.5±13.6years. Mean number of episodes: 7.1±3.6. Mean duration of current episode: 33.4±24.9 weeks. Mean HAM-D basal score: 30.0±5. Each patient underwent a cycle of ECT (mean No. 6.7±3.3). Pharmacological treatment was administered upon clinical need. Response rate 87%, remission rate 43.5%. Three out of 23 (13.04%) patients had transient hypomanic switch, spontaneous recovery within 7days after the last ECT.

Our experience confirms that ECT is a powerful antidepressant, especially in patients with severe long-lasting depression, refractory to treatment. ECT is also a safe procedure: no adverse effects were reported. The manic switch rate is comparable with antidepressant drugs.