Lymphocyte studies in congenital thymic dysplasia: The one-way stimulation test - 07/10/17
Abstract |
Lymphocytes from children with congenital thymic dysplasia were stimulated withmitomycin-C treated lymphocytes in the one-way stimulation test and with phytohemagglutinin (PHA). Cells of a patient with the sex-linked form of congenital thymic dysplasia consistently responded to allogeneic lyphocytes although the response to PHA was usually negative. Lymphocytes of two other patients did not respond to any form of stimulation; conversion of the PHA response took place in one of these children after transfusion with maternal and fetal lymphoid cells and was followed by a fatal graft-versus-host disease. Plasma from these children supported the growth of normal lymphocytes adequately. By our methods the carrier state could not be detected in patient's relatives. There is suggestive evidence that lymphocyte response, as demonstrated by these in vitro tests, depends upon the integrity of the thymus. Failure to respond to PHA in the presence of a response to allogeneic cells suggests functional heterogeneity within the lymphoid system. Allogeneic stimulation may be more useful than PHA in the study of patients with congenital thymic dysplasia.
Le texte complet de cet article est disponible en PDF.Abbreviations used : PHA, TPT, m-C, 3HT, CTD
* | Original studies from the University ofMinnesota laboratories cited here were aided by grants from the United States Public Health Service (HE-06314, HE-02085, AI-00798, AI-07726), The National Foundation, American Cancer Society, Minnesota Chapter of Arthritis and Rheumatism Foundation, and Minnesota Heart Association, and also The Damon Runyon Memorial Fund for Cancer Research (DRG 886A); grants to the University of Wisconsin Medical School were from the National Institutes of Health. |
Vol 72 - N° 2
P. 177-185 - février 1968 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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