The literature on pseudohypoparathyroidism is reviewed with special emphasis on the association of this disorder with hypothyroidism. A case of pseudohypoparathyroidism with hypothyroidism in a 10-year-old girl is reported. Obesity and mental retardation were the presenting symptoms. The characteristic physical, laboratory, and roentgenological findings of pseudohypoparathyroidism were present. The lack of parathyroid effect was indicated by the persistent elevated concentration of inorganic phosphorus and depressed serum calcium concentration despite long-term intramuscular parathormone therapy. Thyroid function was found to be depressed. Serum protein-bound iodine and radioactive iodine uptake values were low. A brief discussion of therapy in pseudohypoparathyroidism is presented. Though the serum values in the patient reported upon returned to normal after therapy with vitamin D and thyroid extract, little effect on the mental status was noted.