Atypical Fibroxanthoma Revisited - 11/10/17
, Luis Requena, MD b, Thomas Brenn, MD, PhD cAbstract |
Atypical fibroxanthoma (AFX) represents a rare mesenchymal neoplasm arising predominantly in the head and neck area of elderly patients. Clinically, the neoplasm is characterized by a rapid and exophytic growth with frequent ulceration of the epidermis. Histopathologically, AFX represents a well-circumscribed, dermal-based neoplasm composed of a variable admixture of large histiocytoid cells, enlarged spindled and epithelioid tumor cells, and multinucleated tumor giant cells with bizarre and pleomorphic nuclei. If strict diagnostic criteria are applied, the clinical behavior of AFX is benign in most cases, and complete excision represents the treatment of choice.
Le texte complet de cet article est disponible en PDF.Keywords : Atypical fibroxanthoma, Pleomorphic dermal sarcoma, Mesenchymal neoplasms, Immunohistochemistry, Differential diagnosis
Plan
| Statements: The authors declare that the study was done according to the ethical standards, there is no funding, and the authors have no conflict of interest. |
Vol 10 - N° 2
P. 319-335 - juin 2017 Retour au numéro
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