Thirty-nine unselected cryptorchids were treated by hypodermic injection of anterior pituitary-like hormone. Twenty-nine (74.3 per cent) were between the ages of eight and fourteen years. Fourteen (36 per cent) were of normal constitution and 25 (64 per cent) presented evidence of endocrine dysfunction (hypopituitary type). Ten (25.6 per cent) of the cryptorchids were unilateral and 29 (74.4 per cent) were bilateral.

Complete descent of the testes occurred in 28 (71.8 per cent); 25 bilateral, 3 unilateral. Partial descent occurred in 4 (10 per cent); 1 bilateral, 3 unilateral. Seven (18.2 per cent) failed to respond to treatment; 3 bilateral, 4 unilateral. Seven patients have been subjected to surgery, and operation is to be performed upon 2 others.

A study of the urinary excretion of gonadotropic hormone is suggested as a valuable adjunct in determining the functional activity of the hypophysis and the gonads. There were no serious unpleasant untoward reactions resulting from therapy. Hormone therapy is a valuable adjunct to surgery, both pre- and postoperatively.