Growth hormone treatment of children with myelomeningocele - 12/10/17
Abstract |
From the National Cooperative Growth Study database 106 patients (53 boys) with myelomeningocele who were treated with recombinant human growth hormone (GH) at 56 centers were identified. Eighty-one patients (41 boys) were prepubertal at enrollment. The mean pretreatment growth rate (GR) in these prepubertal patients was 4.5 ± 3.7 cm/yr, and the mean height SD score was -4.0 ± 1.2. The maximal stimulated GH level was less than 10 μg/L in 71% of these patients and less than 7 μg/L in 49%. The mean chronologic age was 6.5 ± 2.9 years, and the mean height age was 3.4 ± 1.7 years. After GH treatment the year 1 GR in those who remained prepubertal was 8.5 ± 3.3 cm/yr, a significant increase over baseline (p <0.01). This increase was sustained through year 4 and remained significant through year 3 (p <0.01). The height SD score showed sustained significant improvement through year 4, to -2.2 ± 1.4 (p <0.001). The GR and SD score for stature improve with GH treatment in children with myelomeningocele. (J PEDIATR 1996;128:S28-31)
Le texte complet de cet article est disponible en PDF.Abbreviations : GH, GR, NCGS, SDS
Plan
 | From the Department of Pediatrics, Medical College of Pennsylvania and Hahnemann University, Allegheny Campus, Allegheny General Hospital, Pittsburgh, Pennsylvania, and the Department of Biostatistics, Genentech, Inc., South San Francisco, California |
| Supported by Genentech, Inc., and Allegheny Singer Research Institute. |
 | aDeborah Rotenstein, MD, is a past recipient of a clinical trial grant from Genentech, Inc. |
| bTimothy J. Breen, PhD, is employed by Genentech, Inc. |
| ♢ | Reprint requests: Deborah Rotenstein, MD, Department of Pediatrics, Allegheny General Hospital, 320 E. North Ave., Pittsburgh, PA 15212. |
| ♢♢ | 0022-3476/96/$5.00 + 0 9/0/72344 |
Vol 128 - N° 5S
P. S28-S31 - mai 1996 Retour au numéro
Article précédent
- Linear growth in response to growth hormone treatment in children with short stature associated with intrauterine growth retardation: The National Cooperative Growth Study experience
- Steven D. Chernausek, Timothy J. Breen, Graeme R. Frank
- Physiology of growth hormone secretion during sleep
- Eve Van Cauter, Laurence Plat
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