Left Atrial Reverse Remodeling After Catheter Ablation of Nonparoxysmal Atrial Fibrillation in Patients With Heart Failure With Reduced Ejection Fraction - 07/06/18
, Koji Tanaka, MD a, Yuichi Ninomiya, MD, PhD a, Yuko Hirao, MD a, Nobuaki Tanaka, MD a, Masato Okada, MD a, Hiroyuki Inoue, MD a, Ryo Nakamaru, MD a, Yasushi Koyama, MD, PhD a, Atsunori Okamura, MD, PhD a, Katsuomi Iwakura, MD, PhD a, Yasushi Sakata, MD, PhD b, Kenshi Fujii, MD, PhD aAbstract |
The efficacy of catheter ablation (CA) of nonparoxysmal atrial fibrillation (PAF) in patients with left ventricular systolic dysfunction is controversial. We investigated the outcomes of CA for non-PAF in patients with reduced left ventricular ejection fraction (LVEF) and the impact of early left atrial (LA) reverse remodeling on these outcomes. A total of 251 consecutive patients who underwent CA for non-PAF were divided into 2 groups (reduced: preoperative LVEF ≤55%, LVEF: 46.5 ± 8.7%, n = 63; normal: >55%, 65.8 ± 5.8%, n = 188). We analyzed the 4-year atrial fibrillation- or atrial tachycardia (AT)-free survival rate and assessed changes in LVEF, hemodynamics, and LA reverse remodeling at the end of a 90-day blanking period. We also evaluated LA reverse remodeling in patients with and without recurrence. The atrial fibrillation- or AT-free survival rates were similar (reduced vs normal 48% vs 42%, p = 0.32). The reduced group exhibited significant LVEF improvement (before vs after, 46.5 ± 8.7% vs 58.4 ± 11.5%, p <0.001), reduced mitral regurgitation, and spectral tissue Doppler-derived index, and had greater percent maximum left atrial volume reduction (reduced vs normal 25.3 ± 18.2% vs 19.3 ± 16.2%, p = 0.014). Percent maximum left atrial volume reduction was greater in patients without recurrence (with recurrence vs without recurrence 17.3 ± 16.7% vs 25.4 ± 16.1%, p <0.001). In conclusion, the efficacy of non-PAF CA in patients with reduced LVEF was comparable with that in patients with normal LVEF. Greater LA reverse remodeling in these patients suggests an association with a reduced recurrence rate.
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Vol 122 - N° 1
P. 89-96 - juillet 2018 Retour au numéro
Article précédent
- Relation of Left Atrial Appendage Remodeling by Magnetic Resonance Imaging and Outcome of Ablation for Atrial Fibrillation
- Promporn Suksaranjit, Nassir F. Marrouche, Frederick T. Han, Alan Morris, Gagandeep Kaur, Tyson Oswald, Brent D. Wilson
- Usefulness of a Low Resting Heart Rate to Predict Recurrence of Atrial Fibrillation After Catheter Ablation in People ?65 Years of Age
- Jintao Wu, Xianwei Fan, Haitao Yang, Lijie Yan, Xianjing Xu, Hongyan Duan, Shanling Wang, Yingjie Chu
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