Glucotoxicity: Potential Mechanisms - 21/07/18
Doi : 10.1016/S0749-0690(18)30058-2
Arshag D. Mooradian, MD ⁎, Jerome E. Thurman, MD
From the Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri
**Address reprint requests to: Arshag D. Mooradian, MD, Division of Endocrinology, Diabetes, and Metabolism, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104.Division of Endocrinology, Diabetes, and MetabolismSaint Louis University School of Medicine1402 South Grand BoulevardSt. LouisMO63104
Résumé |
Plasma concentration of glucose is found within a relatively narrow range of values for most animal species, yet it has little correlation with maximum lifespan; however, hyperglycemia in most animals is associated with premature death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implications for the aging organism.
Le texte complet de cet article est disponible en PDF.© 1999
Elsevier Inc. Tous droits réservés.
Vol 15 - N° 2
P. 255-264 - mai 1999 Retour au numéro
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