The assessment, diagnosis, and management of orofacial pain (OFP) disorders is often a complex, multifactorial, and multidisciplinary process. Nociception leads to the perception of pain, causing the personal experience of suffering, which results in pain behavior. Many patients present with various comorbidities that may influence these conditions in a multitude of ways. The clinical presentation of OFP often includes biological, psychological, social, behavioral, and belief system components.