Multiple Endocrine Neoplasia Type 2B Presents Early in Childhood but Often Is Undiagnosed for Years - 21/11/18
Doi : 10.1016/j.jpeds.2018.08.022
Angeliki Makri, MD, MSc 1, ** 
, Srivandana Akshintala, MD 2, 3, *, Claudia Derse-Anthony, RN 4, Brigitte Widemann, MD 2, Constantine A. Stratakis, MD 1, John Glod, MD 2, Maya Lodish, MD 1
, Srivandana Akshintala, MD 2, 3, *, Claudia Derse-Anthony, RN 4, Brigitte Widemann, MD 2, Constantine A. Stratakis, MD 1, John Glod, MD 2, Maya Lodish, MD 1 1 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD
2 Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
3 Division of Pediatric Hematology/Oncology, New York University School of Medicine, New York, NY
4 Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD
*Reprint requests: Angeliki Makri, MD, MSc, Building 10, Room 2E-5140, 10 Center Dr, Bethesda, MD 20892.Building 10Room 2E-514010 Center DrBethesdaMD20892
Abstract |
We describe the presenting symptoms and signs of multiple endocrine neoplasia type 2B in a cohort of children. Improved awareness of the early nonendocrine signs of multiple endocrine neoplasia type 2B could lead to earlier diagnosis before the development of medullary thyroid cancer and possibly its metastasis.
Le texte complet de cet article est disponible en PDF.Abbreviations : GI, MEN2B, MSK, MTC
Plan
| Funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The authors declare no conflicts of interest. |
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| Portions of this study were presented at the Pediatric Academic Societies Meeting/Pediatric Endocrine Society Meeting, May 5-8, 2018, Toronto, Canada. |
© 2018
Publié par Elsevier Masson SAS.
Vol 203
P. 447-449 - décembre 2018 Retour au numéro
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