Linked color imaging identifies important risk factors associated with gastric cancer after successful eradication of Helicobacter pylori - 18/10/19
Abstract |
Background and Aims |
Limited studies have evaluated the risk factors of gastric cancer (GC) after eradication of Helicobacter pylori (H pylori) using endoscopic findings. We aimed to investigate GC detection-related endoscopic findings after eradication of H pylori using linked color imaging (LCI), a novel image-enhanced endoscopy.
Methods |
This single-center, cross-sectional study evaluated background mucosa-associated endoscopic findings described in the Kyoto classification of gastritis in patients with newly detected GC after eradication of H pylori (CA group, n = 109) and those without GC (NC group, n = 85) using white-light imaging (WLI) and LCI.
Results |
Severe atrophy and map-like redness were significantly more frequent in the CA group than in the NC group using WLI (79.8% vs 63.5%, P = .01; 61.5% vs 37.7%, P = .001, respectively) and LCI (79.8% vs 63.5%, P = .01; 78.0% vs 45.9%, P < .0001, respectively). Regular arrangement of collecting venules (RAC) was significantly less frequent in the CA group than in the NC group using WLI (40.3% vs 64.7%, P = .0009) and LCI (37.6% vs 62.4%, P = .0006). Map-like redness was an independent positive risk factor (WLI: odds ratio [OR], 2.05; 95% confidence interval [CI], 1.09-3.87; P = .03; LCI: OR, 3.62; 95% CI, 1.88-6.97; P < .001), whereas RAC was an independent negative risk factor (WLI: OR, 0.42; 95% CI, 0.21-0.82; P = .01; LCI: OR, 0.46; 95% CI, 0.23-0.93, P = .03) for detection of GC after eradication of H pylori.
Conclusions |
Map-like redness, which was identified more frequently using LCI than WLI, and the absence of RAC were associated with detection of GC after eradication of H pylori.
Le texte complet de cet article est disponible en PDF.Abbreviations : CI, GC, LCI, OR, RAC, WLI
Plan
| DISCLOSURE: Dr Yoshida received a research grant from Fujifilm Medical (J082003006). Dr Handa has been paid lecture fees by Daiichisankyo. Dr Naito received a scholarship fund from EA Pharma and a collaboration research fund from Fujifilm Medical, and has been paid lecture fees by Janssen Pharma, Mylan EPD, Takeda Pharma, Mochida Pharma, EA Pharma, Otsuka Pharma, Astellas Pharma, and Miyarisan Pharma. Dr Itoh was affiliated with a department that was partially funded by Fujifilm Medical (J082003006). The research was partly funded by these funds. Neither the funding agency nor any outside organization has participated in the study design or has any conflict of interest. All other authors disclosed no financial relationships relevant to this publication. |
Vol 90 - N° 5
P. 763-769 - novembre 2019 Retour au numéro
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