MicroRNA-200c expression is decreased in hepatocellular carcinoma and associated with poor prognosis - 08/11/19
pages | 7 |
Iconographies | 2 |
Vidéos | 0 |
Autres | 0 |
Highlights |
• | miR-200c expression is decreased in hepatocellular carcinoma tissues. |
• | miR-200c expression is associated with tumor size, α-fetoprotein, stage and invasion. |
• | Lower miR-200c expression is associated with worse 2-year survival. |
• | miR-200c expression is an independent prognostic factor for 2-year survival. |
Summary |
Accumulating evidences have shown that microRNA-200c (miR-200c) expression is associated with the prognosis of many types of human cancer. However, the prognostic value of miR-200c in hepatocellular carcinoma (HCC) is still unknown. In the present study, the expression of miR-200c in paired HCC and adjacent non-tumor tissues from 148 patients was determined by quantitative real-time PCR (qRT-PCR), and we analyzed its association with clinicopathological characteristics and prognosis of HCC patients. Our results showed that the expression of miR-200c was significantly decreased in HCC tissues compared with adjacent non-tumor tissues (P < 0.0001). Correlation analysis showed that miR-200c expression was significantly associated with tumor size (P = 0.021), serum AFP level (P = 0.016), TNM stage (P = 0.019) and vein invasion (P = 0.026). Patients with lower miR-200c expression had significantly worse overall survival (OS, P = 0.023) and recurrence-free survival (RFS, P = 0.002). The multivariate Cox regression analysis revealed that miR-200c expression was an independent prognostic factor for OS (hazard ratio (HR) [95% CI] = 2.226 [1.235–4.012], P = 0.008) and RFS (HR [95% CI] = 2.662 [1.618–4.38], P < 0.001). In conclusion, our results suggest that the miR-200c expression was significantly down-regulated and associated with poor prognosis in HCC.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinoma, microRNA-200c, Prognosis, Overall survival, Recurrence-free survival
Plan
Vol 43 - N° 6
P. 715-721 - novembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?