Long non-coding RNA 00152 slicing represses the growth and aggressiveness of hemangioma cell by modulating miR-139-5p - 13/11/19
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Graphical abstract |
Highlights |
• | Linc00152 is overexpressed in infantile hemangioma (IH), especially in the proliferating-phase hemangioma. |
• | Downregulation of linc00152 suppresses the cell viability, migration and invasion of hemangioma cell. |
• | Linc00152 binds with miR-139-5p and linc00152 level is inversely correlated with the level of miR-139-5p in IH. |
• | Linc00152 restrains the aggressiveness of hemangioma cell via interacting with miR-139-5p and modulates the level of TPD52. |
Abstract |
Long non-coding RNA (lncRNA) linc00152 has been recognized as an oncogenic lncRNA in various cancers. This study attempts to investigate the roles of linc00152 in the metastasis-related traits of infantile hemangioma (IH). Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 repressed the growth and lung metastasis of hemangioma cell in vivo. Subsequent analysis revealed that linc00152 bound with miR-139-5p and linc00152 expression was inversely correlated with the level of miR-139-5p in IH. Same effects of miR-139-5p transfection on HemECs cells were observed as downregulation of linc00152. Moreover, tumor protein D52 (TPD52) was confirmed to be the target of miR-139-5p. Besides, the anti-tumor effect of linc00152 silence on hemangioma cell was reversed by rexpression of TPD52. This study demonstrates that downregulatuon of linc00152 restrains the aggressiveness of hemangioma cell in vitro and in vivo via interacting with miR-139-5p and further modulates the level of TPD52.
Le texte complet de cet article est disponible en PDF.Keywords : Linc00152, Growth, Metastasis, Hemangioma, miR-139-5p
Plan
Vol 120
Article 109385- décembre 2019 Retour au numéro
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