Editorial: Mapping the Miswired Connectome in Autism Spectrum Disorder - 20/02/20
Résumé |
Unraveling the altered brain−behavior relationships in autism spectrum disorder (ASD) has been challenging because of the limitations of sample size and methodologies that are still evolving. Recently, pediatric neuroimaging has undergone considerable advancement by harnessing resting-state functional magnetic resonance imaging (rfMRI),1 in which methodologies can be applied to quantify functional connectivity (FC) from spontaneous fluctuations of brain activity. Benefiting from relatively easy data collection from clinical samples and the ability to harmonize these samples, rfMRI has supported the emergence of open pediatric neuroimaging science (OPENS) through the pooling and sharing of large-scale neuroimaging data by and for the research community (eg, the Autism Brain Imaging Data Exchange [ABIDE]2,3). Big data OPENS ASD studies have revealed functional impairments in both sensory and cognitive brain networks. However, whether these impairments reflect a miswired connectome of network interplay in ASD remains to be elucidated.
Le texte complet de cet article est disponible en PDF.| Dr. Zuo’s efforts were supported in part by the Guangxi BaGui Scholarship (201621), the Natural Science Foundation of China (81220108014, 81471740), the Beijing Municipal Science and Tech Commission (Z161100002616023, Z171100000117012), the China - Netherlands CAS-NWO Programme (153111KYSB20160020), the Major Project of National Social Science Foundation of China (14ZDB161), the Roadmap Program of China Association for Science and Technology (2018XKFZ03), the National R&D Infrastructure and Facility Development Program of China - Fundamental Science Data Sharing Platform (DKA2019-12-02-21), and National Program on Key Basic Research Project of China (2015CB351702). |
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| Disclosure: Dr. Zuo has reported no biomedical financial interests or potential conflicts of interest. |
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| All statements expressed in this column are those of the authors and do not reflect the opinions of the Journal of the American Academy of Child and Adolescent Psychiatry. See the Instructions for Authors for information about the preparation and submission of Editorials. |
Vol 59 - N° 3
P. 348-349 - mars 2020 Retour au numéro
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