PET/Computed Tomography in Pulmonary and Thoracic Inflammatory Diseases (Including Cardiac Sarcoidosis) : The Current Role and Future Promises - 05/03/20

Doi : 10.1016/j.cpet.2019.11.008

Ashwini Kalshetty, DNB ^a,^b, Sandip Basu, DRM, DNB ^a,^b,^⁎
^a Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai 400012, India
^b Homi Bhabha National Institute, Mumbai 400094, India

^∗Corresponding author. Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Annexe Building, Jerbai Wadia Road, Parel, Mumbai 400 012, India.Radiation Medicine CentreBhabha Atomic Research CentreTata Memorial HospitalAnnexe BuildingJerbai Wadia RoadParelMumbai400 012India

Résumé

¹⁸F-fluorodeoxyglucose PET/computed tomography (CT) can play a valuable adjunct role in initial and post-treatment assessment of thoracic and pulmonary inflammatory disorders and is particularly helpful when the conventional biomarkers and anatomical imaging are non-contributory or inconclusive. PET/CT can potentially help in chronic obstructive pulmonary disease (COPD). Quantitative regional parameters of inflammation, perfusion, and ventilation estimated by PET/CT have the potential to cause a paradigm shift in the management of COPD. This article highlights the role of PET/CT in thoracic inflammatory disorders, with an overview of newer aspects such as quantification, disease phenotyping, new tracers, and new techniques.

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Keywords : Pulmonary inflammation, Thoracic inflammation, Sarcoidosis, COPD, FDG, PET/CT, FLT-PET, ⁶⁸Ga-DOTANOC PET