Evidenced-Based Screening Strategies for a Positive Family History - 19/05/20

Doi : 10.1016/j.giec.2020.02.015

Jennifer M. Kolb, MD ^a,^⁎ , Dennis J. Ahnen, MD ^a, N. Jewel Samadder, MD, MSc ^b,^c
^a Division of Gastroenterology & Hepatology, University of Colorado Hospital, Anschutz Medical Campus, Aurora, CO, USA
^b Division of Gastroenterology & Hepatology, Mayo Clinic, 5881 East Mayo Boulevard, Phoenix, AZ 85054, USA
^c Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ, USA

^∗Corresponding author. Division of Gastroenterology & Hepatology, University of Colorado Hospital, Anschutz Medical Campus, 1635 Aurora Court, F735, Aurora, CO 80045.Division of Gastroenterology & HepatologyUniversity of Colorado HospitalAnschutz Medical Campus1635 Aurora CourtF735AuroraCO80045

Résumé

The most commonly recognized high-risk group for colorectal cancer (CRC) is individuals with a positive family history. It is generally recognized that those with a first-degree relative (FDR) with CRC are at a 2-fold or higher risk of CRC or advanced neoplasia. FDRs of patients with advanced adenomas have a similarly increased risk. Accordingly, all major US guidelines recommend starting CRC screening by age 40 in these groups. Barriers to screening this group include patient lack of knowledge on family and polyp history, provider limitations in collecting family history, and insufficient application of guidelines.

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Keywords : Advanced adenoma, First-degree relative, Second-degree relative, Colorectal cancer, Colon cancer screening