Double-Dose Desogestrel: Is it Effective in Adolescent Menstrual Dysfunction? - 27/08/21
, C.E. Williams, MBChB MRCOG 2ABSTRACT |
Study Objective |
Adolescent menstrual dysfunction (AMD) is a common cause of iron deficiency anemia and absences from school. The management of AMD with single- and double-dose desogestrel is largely on the basis of anecdotal evidence. Our aim was to describe the effectiveness and safety of both dosing strategies in our clinic cohort to help guide future management.
Design |
Local service evaluation with retrospective analysis of clinic notes.
Setting |
Adolescent gynecology clinic in a tertiary pediatric center in the North West of England.
Participants |
Adolescent girls (10-18 years of age) with AMD (n = 129).
Interventions |
Single-dose (75 µg) desogestrel vs double-dose (150 µg) desogestrel.
Main Outcome Measures |
Prevalence of amenorrhea and light spotting, side effects, and discontinuation rates of both dosing regimens.
Results |
Forty-three of 87 (49%) adolescent girls who started treatment with a double dose of desogestrel were amenorrheic/experienced light spotting, compared with 7/40 (18%) of girls who started treatment with a single dose (P = .001). Patients taking a double dose of desogestrel were less likely to discontinue overall (double: 45/89 [51%]; vs single: 35/40 [88%]; P < .001) and there was no evidence of an increase in nonbleeding side effects (double: 30/89 [34%]; vs single: 15/40 [38%]; P = .68).
Conclusion |
Our findings provide evidence that a double dose of desogestrel is associated with a higher prevalence of amenorrhea and light spotting compared with a single dose in adolescent girls with AMD. However, larger studies are needed to further inform clinical guidelines.
Le texte complet de cet article est disponible en PDF.KeyWords : Adolescence, Menstrual dysfunction, Abnormal uterine bleeding, Desogestrel, Progesterone-only pill, Amenorrhea
Plan
| The authors indicate no conflicts of interest. |
|
| This work was presented, in part, at the Faculty of Sexual and Reproductive Health Annual Scientific Meeting, Edinburgh, United Kingdom, on May 17, 2019, and at the Royal College of Obstetricians and Gynaecology World Congress 2019, London, United Kingdom, on June 18, 2019. |
Vol 34 - N° 5
P. 662-665 - octobre 2021 Retour au numéro
Article précédent
- Adnexal Torsion Predictive Tool Maintains Applicability in a Heterogeneous Pediatric Population
- Nivedita Umasankar, Shannon M. Howard, Kristl V. Tomlin
- Recommendations for Postoperative Surveillance of Pediatric Benign Ovarian Neoplasms
- Maria E. Knaus, Amy E. Lawrence, Amanda J. Onwuka, Naila M. Abouelseoud, Lesley L. Breech, Katherine S. Brito, Charlene Dekonenko, S. Paige Hertweck, Helena Y. Hong, Seema Menon, Diane F. Merritt, Allegra G. Schikler, Nikki Senapati, Yolanda R. Smith, Julie L. Strickland, Amber I. Truehart, Peter C. Minneci, Geri D. Hewitt
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?