Treatment with dry hydrogen peroxide accelerates the decay of severe acute syndrome coronavirus-2 on non-porous hard surfaces - 24/09/21
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Highlights |
• | Severe acute respiratory coronavirus-2 (SARS-CoV-2) is sensitive to dry hydrogen peroxide (DHP) treatment. |
• | Release of DHP between 5 and 25 ppb is effective in inactivating SARS-CoV-2 present on contaminated glass slides. |
• | A contact time of 120 minutes or greater is required for DHP treatment to have demonstrable impact on the residue infectivity of SARS-CoV-2 on contaminated glass slides. |
Résumé |
Background |
Disinfection of contaminated or potentially contaminated surfaces has become an integral part of the mitigation strategies for controlling coronavirus disease 2019. Whilst a broad range of disinfectants are effective in inactivating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), application of disinfectants has a low throughput in areas that receive treatments. Disinfection of large surface areas often involves the use of reactive microbiocidal materials, including ultraviolet germicidal irradiation, chlorine dioxide, and hydrogen peroxide vapor. Albeit these methods are highly effective in inactivating SARS-CoV-2, the deployment of these approaches creates unacceptable health hazards and precludes the treatment of occupied indoor spaces using existing disinfection technologies. In this study, the feasibility of using dry hydrogen peroxide (DHP) in inactivating SARS-CoV-2 on contaminated surfaces in large indoor spaces was evaluated.
Methods |
Glass slides were inoculated with SARS-CoV-2 and treated with DHP between 5 and 25 ppb for up to 24 hours. Residual infectious virus samples were eluted from three replicates at each time point and titrated in African green monkey VeroE6 cells.
Results |
In comparison with the observed relatively high stability of SARS-CoV-2 on contaminated glass slides (control group), residual infectious titers of glass slides inoculated with SARS-CoV-2 were significantly reduced after receiving 120 minutes of DHP treatment.
Conclusions |
The accelerated decay of SARS-CoV-2 on contaminated glass slides suggests that treatment with DHP can be an effective surface disinfection method for occupied indoor spaces
Le texte complet de cet article est disponible en PDF.Keywords : severe acute respiratory syndrome coronavirus-2, dry hydrogen peroxide, inactivation
Plan
| Funding/support: This study was supported by Synexis LLC. The sponsor had no role in study design, experimental procedures, or data analysis. |
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| Conflicts of interest: The authors, Y-J.S.H., A.N.B., W-W.H., S.M.H., J.L.W., S.C.S., S.H., D.L.V., declare no conflict of interest to this manuscript. |
Vol 49 - N° 10
P. 1252-1255 - octobre 2021 Retour au numéro
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