Tumor primary site as a prognostic factor for Merkel cell carcinoma disease-specific death - 12/10/21
, David X. Zheng, BA a, Melissa A. Levoska, MD b, Jeffrey F. Scott, MD c, Jeremy S. Bordeaux, MD, MPH bAbstract |
Background |
Merkel cell carcinoma (MCC) primary site has not been fully investigated as a potential prognostic factor.
Objective |
To determine the incidence by tumor primary site of death due to MCC.
Methods |
We undertook a retrospective analysis of the Survival, Epidemiology, and End Results database. MCC patients treated between 1973 and 2016 were grouped by tumor primary site and a competing risks analysis was performed to test the impact of primary site on disease-specific death. Cumulative incidence of Merkel cell carcinoma-specific mortality (CMMI) at 5 years was estimated for each primary site.
Results |
Of 9407 MCC patients identified, 6305 (67.0%) had localized disease, 2397 (25.5%) had regional metastasis, and 705 (7.5%) had distant metastasis. Tumor primary site was predictive of CMMI and varied by stage at diagnosis. Tumors involving the scalp/neck carried the highest CMMI among localized MCC (26.0%). Tumors involving the lip had the highest CMMI among MCC with regional metastasis (56.7%) and distant metastasis (82.1%).
Limitations |
Tumor size data were missing for a large proportion of patients, precluding stratification by stage according to current American Joint Committee on Cancer guidelines.
Conclusions |
Probability of MCC disease-specific death varies by primary site. The primary site of the tumor may be useful as a prognostic indicator for MCC.
Le texte complet de cet article est disponible en PDF.Key words : Merkel cell carcinoma, Merkel cell carcinoma survival, tumor primary site, tumor site, unknown primary site
Abbreviations used : CMMI, IQR, MCC, SEER, sHR
Plan
| Funding sources: None. |
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| IRB approval status: Exempt, due to the use of publicly available and deidentified data. |
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| Reprints not available from the authors. |
Vol 85 - N° 5
P. 1259-1266 - novembre 2021 Retour au numéro
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