Beyond the Clinical Trials : Off-Protocol Therapeutic Hypothermia - 22/02/22
, John D.E. Barks, MDRésumé |
Mild therapeutic hypothermia has been extensively studied and validated as an effective and safe treatment for term and near-term infants with moderate and severe hypoxic encephalopathy meeting narrow inclusion criteria. Unanswered questions remain about whether cooling treatment can be optimized to improve outcomes even further, and whether it is reasonable to offer treatment to infants excluded from the foundational studies. Consideration of “off-protocol” cooling practices requires methodical review of available evidence and analysis using both a clinical and a research ethical framework.
Le texte complet de cet article est disponible en PDF.Keywords : Therapeutic hypothermia, Hypoxic ischemic encephalopathy, Research ethics, Neuroprotection, Targeted temperature management
Plan
| Attestations: Dr N.T. Laventhal contributed substantially to the conception or design of the work and drafted the work and approved the final version to be published. Dr J.D.E. Barks contributed substantially to the conception or design of the work and revised it critically for important intellectual content and approved the final version to be published. |
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| COI statement: The authors have no conflicts of interest to disclose. |
Vol 49 - N° 1
P. 137-147 - mars 2022 Retour au numéro
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