Clinical characteristics and symptom duration among outpatients with COVID-19 - 31/03/22
, Krystal Hunter b, Elizabeth Leilani Lee, MD a, Daniel Hyman, DO a, Peter Bross, MD a, Andrew Alabd, MD a, Melanie Betchen, MD a, Vittorio Terrigno, MD a, Shikha Talwar, MD a, Daniel Ricketti, MD a, Bennett Shenker, MD c, Thomas Clyde, MD a, Brian W Roberts, MD, MSc d
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Highlights |
• | Patients were followed until complete symptom resolution from COVID-19 rather than at pre-set time periods. |
• | The conclusions focus on practical advice for patients that can be used in daily practice in terms of symptom expectations. |
• | This study found that the median symptom duration was 15 days --this suggests persons with COVID-19 may remain symptomatic longer than their isolation period. |
Résumé |
Background |
Approximately 80% of people with COVID-19 do not require hospitalization. Studies examining the outpatient experience have not tracked symptoms to resolution leading to unknown expected symptom duration. Our objectives were to (1) determine symptom duration among patients with COVID-19 who do not require hospitalization and (2) identify potential risk factors associated with prolonged symptom duration.
Design |
This is a retrospective cohort study conducted across an academic healthcare system including adult patients with laboratory‐confirmed SARS-CoV-2 infection between March 18th and April 28th, 2020 who were not hospitalized. Symptom duration encompassed time from patient-reported symptom onset as documented in the chart until documented symptom resolution. We calculated the median symptom duration and tested if demographics, comorbidities, or reported symptoms were associated with symptom duration.
Key results |
Of 294 patients meeting inclusion criteria, 178 (60.5%) had documented symptom resolution. The median [interquartile range (IQR)] symptom duration for included patients was 15 (8-24) days. No associations were found between comorbidities and symptom duration. Factors associated with prolonged symptom duration were presence vs lack of lower respiratory symptoms [median (IQR) 16.5 (10.75-33.5) vs 14.5 (7-21.75) days respectively, P < .001] and neurologic symptoms [median (IQR) 17 (9-28) vs 9.5 (4-17) days, P < .001] at disease onset.
Conclusions |
The median symptom duration in outpatients is 15 days and over 25% of patients have symptoms longer than 21 days.
Le texte complet de cet article est disponible en PDF.Key Words : Coronavirus infections, Risk factors, Ambulatory care, Recovery of function, Outpatients statistics and numerical data
Plan
| Conflicts of interest: The authors have no conflicts of interest to disclose. |
Vol 50 - N° 4
P. 383-389 - avril 2022 Retour au numéro
Article précédent
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