Alpha-tocopherol: roles in prevention and therapy of human disease - 23/04/08
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Abstract |
Alpha-tocopherol, one of the eight isoforms of vitamin E, is the most potent fat-soluble antioxidant known in nature. For years, it was thought that -tocopherol only functioned as a scavenger of lipid peroxyl radicals, specifically, oxidized low-density lipoprotein (oxLDL), thereby serving as a chief antioxidant for the prevention of atherosclerosis. In recent years, the many roles of -tocopherol have been uncovered, and include not only antioxidant functions, but also pro-oxidant, cell signaling and gene regulatory functions. Decades of clinical and preclinical studies have broadened our understanding of the antioxidant vitamin E and its utility in a number of chronic, oxidative stress-induced pathologies. The results of these studies have shown promising, albeit mixed reviews on the efficacy of -tocopherol in the prevention and treatment of heart disease, cancer and Alzheimer’s disease. Future studies to uncover cellular and systemic mechanisms may help guide appropriate clinical treatment strategies using vitamin E across a diverse population of aging individuals.
Le texte complet de cet article est disponible en PDF.Keywords : Cardiovascular disease, Alzheimer’s disease, Cancer, Oxidative stress
Plan
Vol 59 - N° 7
P. 380-387 - août 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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