Disseminated histoplasmosis in an AIDS patient with immunologic non-response to HAART: A case report - 17/08/22
Background |
Histoplasmosis in Africa is caused by Histoplasma capsulatum var duboisii (Hcd) and/or Histoplasma capsulatum var capsulatum (Hcc) [1]. It occurs predominantly in immunocompetent patients as localized disease and less commonly in HIV positive patients as disseminated disease [2]. The most significant risk factor for histoplasmosis in Africa is HIV [3]. Histoplasmosis is often mis-diagnosed and treated empirically as tuberculosis (TB) in HIV patients in TB endemic areas [2,3]. The advent of highly active antiretroviral therapy (HAART) has not been associated with a significant decline in the incidence of histoplasmosis globally thus underscoring the importance of diagnosing this treatable condition in endemic regions [4]. We report a case of disseminated histoplasmosis in an AIDS patient with good clinical response to antifungal therapy but failure of immune reconstititution with HAART.
Le texte complet de cet article est disponible en PDF.Keywords : Histoplasmosis, Disseminated histoplasmosis, HIV/AIDS
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Vol 32 - N° 3
Article 101271- août 2022 Retour au numéro
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