Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study - 09/11/22
, Robert Gallop 2, Siobhan Sutcliffe 3, Karl J. Kreder 4, H. Henry Lai 5, J. Quentin Clemens 6, Bruce D. Naliboff 7for the
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network⁎
Abstract |
Objective |
To characterize Urologic Chronic Pelvic Pain Syndrome (UCPPS) pain and urinary symptom trajectories with up to 9 years of follow-up and evaluate whether initial 1-year trajectories are associated with longer-term changes.
Materials and Methods |
Data were analyzed from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Network's prospective observational protocols including the Epidemiology and Phenotyping Study (EPS; baseline to Year 1), EPS Extension (EXT; Years 1-5), and Symptom Patterns Study (SPS: 3-year study; Years 3-9). Adults with Interstitial Cystitis/Bladder Pain Syndrome or Chronic Prostatitis/Chronic Pelvic Pain Syndrome provided patient-reported assessments biweekly (EPS), every 4 months (EXT), or quarterly (SPS). Primary outcomes were composite pain (0-28) and urinary (0-25) severity scores. Multi-phase mixed effects models estimated outcomes over time, adjusted for baseline severity and stratified by EPS symptom trajectory.
Results |
163 participants (52% women; mean ± SD age 46.4 ± 16.1 years) completed EPS and enrolled in EXT; 67 also enrolled in SPS. Median follow-up was 4.6 years (range 1.3-9.0). After 1 year: 27.6%, 44.8% and 27.6% and 27.0%, 38.0% and 35.0% were improved, stable or worse in pain and urinary symptom severity, respectively. On average, pain and urinary symptom scores did not change further during EXT and SPS periods.
Conclusions |
Women and men with UCPPS showed remarkable stability in pain and urinary symptom severity for up to 9 years, irrespective of their initial symptom trajectory, suggesting UCPPS is a chronic condition with stable symptoms over multiple years of follow-up.
Le texte complet de cet article est disponible en PDF.Abbreviations : CPPS, EPS, EXT, GUPI, IC/BPS, ICDB, ICSI, IQR, MAPP, PPS, QOL, SPS, SD, UCPPS, USS
Plan
| Funding information: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH). |
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| Grant/Award Numbers: U01 DK082315, U01 DK082316, U01 DK082325, U01 DK082333, U01 K082342, U01 DK082344, U01 DK082345, U01 DK082370, U01 DK103227, U01 DK103260, U01 DK103271 |
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| Abstract presented at the American Urogynecologic Society (AUGS) PFD Week 2020, Virtual meeting, October 6-10, 2020. |
Vol 169
P. 58-64 - novembre 2022 Retour au numéro
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