Therapeutic effects of traditional Chinese medicine on gouty nephropathy: Based on NF-κB signalingpathways - 13/01/23
Abstract |
As the final product of purine metabolism, excess serum uric acid (SUA) aggravates the process of some metabolic diseases. SUA causes renal tubule damage, interstitial fibrosis, and glomerular hardening, leading to gouty nephropathy (GN). A growing number of investigations have shown that NF-κB mediated inflammation and oxidative stress have been directly involved in the pathogenesis of GN. Traditional Chinese medicine’s treatment methods of GN have amassed a wealth of treatment experience. In this review, we first describe the mechanism of NF-κB signaling pathways in GN. Subsequently, we highlight traditional Chinese medicine that can treat GN through NF-κB pathways. Finally, commenting on promising candidate targets of herbal medicine for GN treatment via suppressing NF-κB signaling pathways was summarized.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | NF-κB mediates multiple pathological process to promote kidney injury in GN. |
• | Chinese medicine reducesinflammatory response and oxidative stressin GN via acting on NF-κB-related pathways. |
• | New targets of Chinese medicine are discussed to provide a basis for studies of NF-κBpathways in GN. |
Abbreviations : GN, NF-κB, UA, HUA, IL-1β, TNF-α, IL-6, ICAM-1, VCAM-1, ROS, MSU, TLR2, TLR4, IL-1R, IRAK, TRAF6, IKK, IκB, ASC, MAPK, COX-2, iNOS, TXNIP, Scr, SIRT1, MCP-1, URAT1, GLUT9, OAT1, ABCG2, OCT1, OCTN1/2, BUN, β2-MG, HCY, eGFR, ESR, CRP, SOD1
Keywords : Gouty nephropathy, Uric acid, Hyperuricemia, NF-κB signaling pathways, Herbal medicine
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Vol 158
Article 114199- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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