Nano-vitamin C: A promising candidate for therapeutic applications - 13/01/23
Abstract |
Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by low chemical stability. Several nano-encapsulation techniques have been described in the literature and yet, there are only a handful of clinical investigations dedicated to unlocking the therapeutic applications of nano-encapsulated vitamin C. Clearly, further investigations are warranted in order to affirm the promising clinical potential of nano-encapsulated vitamin C. In this review, we describe the mechanisms of vitamin C activity as a modulator of crucial therapeutic uses in biological systems. We look at key factors affecting the chemical stability of vitamin C alone and in nano-encapsulated and explore pre-clinical and clinical evidence on current vitamin C nano-formulations along with their therapeutic applications. Finally, we critically appraise the gaps and opportunities prevailing in nano-vitamin C research and its potential translation towards relevant clinical outcomes.
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Abbreviations : 8-OHdG, AA, Au-NPs, Bcl-Xl, DL, EE, EMC, FDA, HIF-1α, HMP-L, IGF-1, JHDM, LMP-L, PDI, RAIL, RH, TET, URTI, ZP
Keywords : Vitamin C, Nano-vitamin C, Therapeutic, Clinical, Nanomedicine
Plan
Vol 158
Article 114093- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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