Effects of Ovarian Tissue Cryopreservation on Primary Ovarian Insufficiency in Girls Undergoing Bone Marrow Transplantation - 15/01/23
, Jessica Shim 2, Lan Anh Galloway 3, Holly Hoefgen 4, Vrunda Patel 5, Lesley Breech 6, Veronica Gomez-Lobo 7Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder
Abstract |
Objective |
To determine if removing an ovary for ovarian tissue cryopreservation (OTC) increased rates of primary ovarian insufficiency (POI) in girls undergoing bone marrow transplantation (BMT). Institutional review board approval was obtained from all 3 clinical sites.
Design |
Multicenter retrospective cohort study
Setting |
Academic children's hospitals
Patients |
Females aged 2-21 who underwent BMT with or without OTC from 2010 to 2017.
Interventions |
None
Main Outcome Measures |
Rates of POI in girls who underwent OTC vs those who underwent BMT alone as determined by serum markers, presence of menses, or clinical diagnosis.
Results |
A total of 142 patients were identified, 43 who had OTC and 99 with BMT alone. The rate of POI in girls undergoing OTC was 65% vs 41.8% in those who underwent BMT alone (P = .26).
Conclusions |
Although this study was not powered to detect a lack of difference, it is reassuring that there does not seem to be a clinically significant increase in POI in patients undergoing OTC.
Le texte complet de cet article est disponible en PDF.Key Words : Ovarian tissue cryopreservation, Fertility preservation, Premature ovarian insufficiency, Bone marrow transplant
Plan
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