Symptoms of anxiety and generalized anxiety disorder (GAD) are known to be highly prevalent among patients with chronic pain. GAD frequently co-occurs with depression, a comorbidity contributing to negative pain-related outcomes and poor quality of life. It remains unclear, however, whether specific cognitive, affective, and/or behavioral features associated with GAD play a predominant (i.e., central) role in chronic pain patients' symptom profiles. It is also unclear whether some of these features are more likely to underlie the comorbidity with major depression. The first objective of this study was to characterize GAD symptom profiles and the interrelations across GAD symptoms among patients with chronic pain. The GAD features differentiating patients with and without anhedonia, a key feature of depression, were also examined. This study included 729 patients with chronic pain referred for psychiatric evaluation. Patients' sociodemographic and clinical characteristics were assessed, and patients underwent a structured diagnostic interview with a psychiatrist. The interview was designed to assess the presence/absence of specific mental disorders, including GAD and major depression, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Network analyses using the IsingFit package revealed that excessive worry, lack of control over worry/anxiety, and restlessness were the most influential feature of the GAD network. Results indicated that excessive worry was the main GAD feature differentiating patients with and without anhedonia. Our findings suggest that a subset of cognitive-affective factors play a predominant role in GAD and anhedonia among patients with chronic pain. These factors should be targeted using specific interventions.