Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis - 06/05/08
, Abdurrahman Tufan, Umut Kalyoncu, Omer Karadag, Ali Akdogan, Mehmet Akif Ozturk, Sedat Kiraz, Ihsan Ertenli, Meral Calguneri
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Abstract |
Aims |
The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis.
Methods |
The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49±13) and 30 active AS patients (males/females: 15/15, mean age: 36±12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52±8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41±7) as control groups for RA and AS, respectively.
Results |
MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=−0.507; p=0.004).
Conclusion |
Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Ankylosing spondylitis, Mean platelet volume, Acute phase reactants
Plan
Vol 75 - N° 3
P. 291-294 - mai 2008 Retour au numéro
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