The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis - 19/11/23
, Piumi Nakandala c, Kavinda Malwanage d, Aron T. Hill e, f, Deborah N. Ashthree b, Melissa M. Lane b, Nikolaj Travica b, Elizabeth Gamage b, Wolfgang Marx b, Shapour Jaberzadeh aAbstract |
Objectives |
To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).
Methods |
The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.
Results |
Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.
Discussion and Conclusion |
A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.
Significance |
A-tDCS can be used as a standalone and adjunct treatment for KOA.
Study registration |
PROSPERO number CRD42021255114
Le texte complet de cet article est disponible en PDF.Keywords : Osteoarthritis, Knee, Transcranial direct current stimulation, tDCS, Pain
Plan
Vol 53 - N° 6
Article 102921- décembre 2023 Retour au numéro
Article précédent
- Efficacy of transcranial direct current stimulation in patients with knee osteoarthritis: A systematic review
- Fatemeh Rahimi, Meissam Sadeghisani, Atefeh Karimzadeh
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