Moderate wine consumption measured using the biomarker urinary tartaric acid concentration decreases inflammatory mediators related to atherosclerosis - 07/12/23

Doi : 10.1016/j.jnha.2023.100003

Inés Domínguez López ^a,^b,^c, Camila Arancibia-Riveros ^a,^b, Rosa Casas ^b,^c,^d, Polina Galkina ^a,^b, Maria Pérez ^a,^b,^c, Miguel Ángel Martínez-González ^c,^e, Montserrat Fitó ^c,^f, Emilio Ros ^c,^g, Ramon Estruch ^b,^c,^d,^⁎ , Rosa M. Lamuela-Raventós ^a,^b,^c,⁎
^a Polyphenol Research Group, Departament de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmacia, Universitat de Barcelona (UB), Av. de Joan XXII, 27-31, 08028 Barcelona, Spain
^b Institut de Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), 08921 Santa Coloma de Gramanet, Spain
^c CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
^d Department of Internal Medicine, Hospital Clinic, Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain
^e Department of Preventive Medicine and Public Health, University of Navarra, IdiSNA, 31008 Pamplona, Spain
^f Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas (IMIM), 08007 Barcelona, Spain
^g Lipid Clinic, Endocrinology and Nutrition Service, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, 08036 Barcelona, Spain

^⁎Corresponding author at: Department of Nutrition, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.Department of Nutrition, Faculty of Pharmacy, University of BarcelonaAv. Joan XXIII, 27-31Barcelona08028Spain^⁎⁎Corresponding author at: Department of Internal Medicine, Hospital Clinic, Barcelona, Spain.Department of Internal MedicineHospital ClinicBarcelonaSpain

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Thursday 07 December 2023
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder

Abstract

Objectives

Several studies suggest that moderate wine consumption, particularly red wine, may have benefits for cardiovascular health. Red wine contains a variety of bioactive compounds, including polyphenols like phenolic acids, which have demonstrated anti-inflammatory effects in experimental models. The aim of this study was to assess the anti-inflammatory properties of wine, measured as urinary tartaric acid, a new biomarker of wine consumption.

Design, settings, and participants

One-year longitudinal study that included 217 participants from the PREDIMED trial.

Measurements

Plasma inflammatory biomarkers and urinary tartaric acid were analyzed using xMAP technology and high-performance liquid chromatography, respectively. Multivariable regression analyses were performed to assess the relationship between variations over 1-year in urinary tartaric acid concentrations and 1-year changes in serum inflammatory molecules, including adhesion cell molecules, interleukine-6, tumour necrosis factor alpha, and monocyte chemotactic protein 1. Three categories were built according to tertiles of 1-y changes in urinary tartaric acid.

Results

Using a ROC curve, urinary tartaric acid was corroborated as a reliable biomarker of wine consumption (AUC = 0.818 (95% CI: 0.76; 0.87). In the continuous analysis, participants with higher increases in tartaric acid significantly reduced their concentrations in soluble vascular adhesion molecule (sVCAM-1) after 1-year of follow-up (−0.20 (−0.38; −9,93) ng/mL per 1-SD increment, p-value = 0.031). Moreover, tertiles 2 and 3 of 1-year changes in tartaric acid presented a significant reduction in soluble intercellular cell adhesion molecule (sICAM-1) as compared to tertile 1 (−0.31 (−0.52; −0.10) ng/mL, p-value = 0.014 and −0.29 (−0.52; −0.07) ng/mL, p-value = 0.023, respectively). Participants in the third tertile also exhibited a reduced concentration of sVCAM-1 compared to those in the first tertile (−0.31 (−0.55; −0.06) ng/mL, p-value = 0.035).