Relationship between muscle mass ratio and rocuronium dose required for maintaining deep neuromuscular blockade: A prospective observational study - 20/03/24
, Jung-Won Hwang b, c, Sun Woo Nam aHighlights |
• | No relationship exists between muscle mass ratio and rocuronium dose for deep NMB. |
• | The time of rocuronium onset positively correlates with muscle mass ratio. |
• | The time of rocuronium onset negatively correlates with fat mass ratio. |
• | Actual body weight has no correlation with rocuronium dose, onset, and duration. |
Abstract |
Background |
Deep neuromuscular blockade (NMB) has benefits in various surgical procedures, however, precise quantitative neuromuscular monitoring is crucial for its proper maintenance and recovery. Neuromuscular blocking agent dosage relies on actual body weight (ABW), but this varies among individuals. Therefore, this study hypothesizes that there is a correlation between the rocuronium requirement for deep NMB and muscle mass ratio measured by bioelectric impedance analysis.
Methods |
Ninety adult female patients undergoing laparoscopic operation were enrolled in this study. Muscle and fat masses were assessed using a body composition analyser. Deep NMB, defined as a post-tetanic count of 1–2, was maintained through the continuous infusion of rocuronium. The primary outcome involves determining the correlation between the rocuronium dose required for deep NMB and the muscle mass ratio. Conversely, secondary outcomes included assessing the relationship between the rocuronium dose for deep NMB and fat mass ratio, and ABW. Additionally, we investigated their relationship with rocuronium onset time and profound blockade duration.
Results |
No relationship was observed between the muscle mass ratio and rocuronium dose required for maintaining deep NMB (r = 0.059 [95% CI = 0.153–0.267], p = 0.586). Fat mass ratio and ABW showed no correlation with the rocuronium dose, whereas rocuronium onset time was positively correlated with muscle mass ratio (r = 0.327) and negatively correlated with fat mass ratio (r = −0.302), respectively. Profound blockade duration showed no correlation with any of the assessed variables.
Conclusions |
No correlation was detected between muscle mass ratio and the rocuronium dose required to achieve deep NMB.
Le texte complet de cet article est disponible en PDF.Keywords : Body composition, Deep blockade, Fat, Muscle, Neuromuscular blockade, Rocuronium
Plan
| ☆ | The institution where the work was performed is Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. |
Vol 43 - N° 3
Article 101368- juin 2024 Retour au numéro
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